Welcome to the Fraser Lab! We are part of the Department of Bioengineering and Therapeutic Sciences. Research in the lab is focused on discovering the fundamental principles of macromolecular structure and dynamics. We are interested in defining conformational states that are essential for function and understanding how conformational transitions couple to biological mechanisms.

Mechanisms underlying the neurochemical logic of behavior. Our goal is to understand how neuromodulators control behavior, and in particular how neuropeptide signaling is regulated in the brain. We seek to understand how the behavioral outputs of a neural circuit are encoded by the diversity of neurotransmitters that they express, and to investigate the cellular and molecular mechanisms that govern neuropeptide signaling in behavior and aging. Signaling in the Aging Brain.

The Molecular Logic of Cellular Signaling Systems.

Center for Structures of Membrane Proteins. The Macromolecular Structure Group is part of the Department of Biochemistry and Biophysics. In the School of Medicine. At the University of California, San Francisco. NMR, Mass Spectrometry, and Molecular Biology. Structure, dynamics, and the c.

TIRF of FRAPed actin filaments in vitro assay. Reflection interference contrast microscopy of Naegleria on Connie the Confocal. Real time, then sped up 20 fold. Naegleria crawling through 3D collagen fibers. Neutrophil crawling, rendered using ChimeraX and Cinema4D. University of California, San Francisco.

I am interested in inventing new methods to construct and manipulate biological molecules at the nanometer scale. To learn more, check out the Douglas Lab. At UCSF in the department of Cellular and Molecular Pharmacology. Two of my favorite projects are BIOMOD.

University of California, San Francisco. UCSF Center for Systems and Synthetic Biology. Lei S Qi Lab at UCSF. We are part of the UCSF Center for Systems and Synthetic Biology. And UCSF Cellular and Molecular Pharmacology. UCSF Center for Systems and Synthetic Biology i. S one of the NIH-NIGMS funded national centers.